The objective of this protocol is to study urothelial cancer with detailed epidemiologic data and tumor and normal tissues available for genomic sequencing to study the etiology, pathogenesis, diagnosis, treatment, and prognosis of cancers in the bladder, upper urinary tract, and urethra. We will perform systematic genetic and epidemiological data collection on 3 groups of subjects 1)Urothelial cancer patients receiving care at Penn State Health 2)Relatives of patients with urothelial cancer 3)High risk-cohort of individuals with family history of urothelial cancers or inherited cancer syndromes (such as Lynch syndrome) candidates for urothelial cancer screening evaluation
