Clinical Studies Search

Protocol Summary


Protocol No.
PSCI-20-059
Prinicipal Investigator
Dandekar, Smita
Phase
N/A
Age Group
Children
Scope
National
Secondary Protocol No.
ALTE16C1
Title
ALTE16C1, Effects of Modern Chemotherapy Regimens on Spermatogenesis and Steroidogenesis in Adolescent and Young Adult (AYA) Survivors of Osteosarcoma
Objective
Primary Aims
Determine whether infertility and/or biomarkers of spermatogenesis and steroidogenesis differ in male osteosarcoma survivors treated with cisplatin with or without ifosfamide compared to male controls without a history of cancer.

Evaluate whether cisplatin with or without ifosfamide for the treatment of osteosarcoma alters sperm DNA methylation.

Exploratory Aim
Evaluate the role of genetic susceptibility in the development of impairments in spermatogenesis or steroidogenesis with contemporary regimens for the treatment of osteosarcoma.
Applicable Disease Sites
Bones and Joints
Status
Open
Participating Institutions
Hershey Medical Center