Clinical Studies Search

Protocol Summary


Protocol No.
PSHCI-15-086
Prinicipal Investigator
Brown, Valerie
Phase
Pilot
Age Group
Both
Scope
National
Secondary Protocol No.
NMTRC012
Title
A Pilot Study Using Molecular Guided Therapy with Induction Chemotherapy Followed by Maintenance with DFMO for Subjects with Newly Diagnosed High-Risk Neuroblastoma
Objective
Primary:
To determine the feasibility of identifying a targeted agent by molecular methods and incorporating that agent into standard upfront high risk neuroblastoma treatment in cycles 3-6 of induction. Following standard consolidation therapy with ASCT, XRT (if indicated) and standard maintenance therapy with Ch14:18 antibody and cis-retinoic acid, the feasibility of adding further maintenance therapy with DFMO will also be assessed.
Secondary:
Monitor for acute toxicity
To measure the response of treatments chosen
(Voluntary) To explore the relationship between tumor phenotype/genotype and response by permitting use of tumor tissue in a correlative biologic study
Applicable Disease Sites
Abdominal

Brain and Nervous System

Head and Neck

Ill-Defined Sites

Lung

Soft Tissue
Status
Open
Participating Institutions
Hershey Medical Center